CKMB(8D10)兔单克隆抗体

Creatine kinase (CK) is a dimeric enzyme expressed by diverse tissues and cell types with calculated molecular weight of 86 KD for dimer and 43 KD for monomer. CK converts creatine to phosphocreatine by consuming ATP. It has two distinct types of subunits CKM (muscle type) and CKB (brain type), generating three combinations: CKMM, CKMB, CKBB. CKBB is found in brain and smooth muscle as well as in other tissues and cells such as neuronal cells, retina, kidney, and bone. CKMM is predominantly expressed in skeletal and cardiac muscles. CKMB heterodimer is found prominently in heart and released upon myocardial infarc-tion. CKMB is an important serum marker for myocardial infarction.